Can Soluble Klotho Protein Be a Potential Tumor Biomarker?
نویسندگان
چکیده
منابع مشابه
Can soluble Klotho protein be a potential tumor biomarker?
262 Am J Clin Pathol 2013;139:259-262 © American Society for Clinical Pathology for us is to try to compare sKL levels in normal people and patients with cancer. However, the concern with this is that because the sKL level could be affected by many factors such as age, diabetes, kidney disease, and others,5 in patients with cancer the sKL level would vary because of such factors, in addition to...
متن کاملKlotho Protein,A Biomarker for AKI
Klotho is an anti-aging single-pass membrane protein that is mainly produced in the kidney. The level of soluble klotho decreases with age and the klotho gene is associated with an increased risk of age-related diseases, such as diabetes, skin atrophy, chronic kidney disease, ataxia and cancer. The klotho gene is composed of five exons and encodes a membrane glycoprotein located in the plasma ...
متن کاملSoluble klotho may be a marker of phosphate reabsorption
Background: Membrane-bound α-klotho functions as a co-receptor with fibroblast growth factor receptor at the renal tubule conferring specificity to fibroblast growth factor-23 (FGF-23), allowing it to inhibit tubular phosphate reabsorption at physiological concentrations. α-klotho also exists as a soluble protein. However, the complex interrelationships between soluble α-klotho (sKl), FGF-23 an...
متن کاملSoluble Klotho protein as a novel serum biomarker in patients with acromegaly
Acromegaly is a chronic disease caused by overproduction of growth hormone, in most cases due to excessive secretion from a pituitary ad-enoma [1, 2]. The incidence of acromegaly is approximately 5 cases per million per year, and the prevalence is estimated to be about 60 cases per million [3]. Growth hormone (GH) induces the synthesis of insulin-like growth factor-1 (IGF-1), which leads to sev...
متن کاملSLC2A4 Polymorphisms Can Be a New Molecular Biomarker for Sports Genomics
"SLC2A4 Polymorphisms Can Be a New Molecular Biomarker for Sports Genomics" is an "Editorial Article" and hasn't abstract.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2013
ISSN: 1943-7722,0002-9173
DOI: 10.1309/ajcp7ecvlf1bpsae